Drugs Exp Clin Res. 1992;18 Suppl:23-9.
Teratological evaluation of Ukrain in hamsters and rats.
Juszkiewicz T, Minta M, Wlodarczyk B, Biernacki B.
Department of Pharmacology and Toxicology, National Veterinary Institute, Pu?awy,
The compound Ukrain, containing thiophosphoric acid alkaloid derivatives from the
plant Chelidonium majus L., was given intramusculary (i.m.) on days 6-11 of
gestation to hamsters and on days 6-15 of gestation to rats in doses of 0.1, 1.67
and 28 mg/kg daily. No clinical signs of toxicity were found in treated animals
and no teratogenic effect could be noted in either species. Such parameters as
the number of corpora lutea, implantation sites, pre and post-implantation
losses, number of live foetuses per litter, placental weight, foetal weight and
crown-rump length were not significantly different between the Ukrain treated
rats and the controls. Slight embryotoxic effects (increased post-implantation
losses) and in consequence decreased number of average litter size were noted in
hamsters exposed to Ukrain at doses which were otherwise not embryotoxic to rats.