Br J Cancer. 2009 Mar 24;100(6):865-9. Epub 2009 Feb 24.
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Why are tumour blood vessels abnormal and why is it important to know?
Nagy JA, Chang SH, Dvorak AM, Dvorak HF.
for Vascular Biology Research, Beth Israel Deaconess Medical Center and
Harvard Medical School, Baston, Massachusetts 02215, USA.
blood vessels differ from their normal counterparts for reasons that
have received little attention. We report here that they are of at
least six distinct types, we describe how each forms, and, looking
forward, encourage the targeting of tumour vessel subsets that have
lost their vascular endothelial growth factor-A (VEGF-A) dependency and
so are likely unresponsive to anti-VEGF-A therapies.