Effects of the conventional antitumor therapies surgery, chemotherapy, radiotherapy and immunotherapy on regulatory T lymphocy..

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Anticancer Res. 2009 May;29(5):1847-52.

of the conventional antitumor therapies surgery, chemotherapy,
radiotherapy and immunotherapy on regulatory T lymphocytes in cancer

Lissoni P, Brivio F, Fumagalli L, Messina G, Meregalli S, Porro G, Rovelli F, Vigorè L, Tisi E, D'Amico G.
Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, 20052 Monza, Milan, Italy.

Several clinical studies have clearly demonstrated that the immune
status is one a major prognostic factor for the survival time in cancer
patients. However the main clinical problem is to identify the most
prognostically important index within the great number of immune
parameters. Recently the evaluation of regulatory T (T-reg) (CD4CD25)
lymphocyte count and function with respect to the T helper (TH) (CD4)
number has been shown to represent the main immune parameters capable
of representing the functional status of the anticancer immunity in
cancer patients. This study evaluated the influence of the four main
conventional anticancer therapies (surgery, chemotherapy, radiotherapy,
immunotherapy) on the CD4/CD4CD25 ratio.
study included 70 patients. The oncological treatments consisted of
surgery in 14, chemotherapy in 36, radiotherapy in 12 and immunotherapy
(subcutaneous low-dose, S.C.-low, interleukin, IL-2) in 8 patients. The
normal value of the CD4/CD4CD25 ratio was greater then 4.0.
Surgery induced a significant decline in the CD4/CD4CD25 mean ratio.
Radiotherapy also induced also a dramatic significant decrease in the
CD4/CD4CD25 ratio, whereas the effect of both chemotherapy and
immunotherapy reflected the clinical response to the treatments. The
CD4/CD4CD25 mean ratio was significantly enhanced in the patients who
obtained control of the neoplastic growth, whereas it diminished in
progressing patients.
CONCLUSION: The commonly used anticancer
therapies profoundly modify the levels of amounts of T-reg lymphocytes.
Because of the fundamental role of T-reg cells in suppressing the
anticancer immunity, thus diminishing survival, the monitoring of the
CD4/CD4CD25 ratio could constitute an important clinical index during
conventional anticancer therapies to predict the prognosis of cancer