Integr Cancer Ther. 2009 Mar;8(1):88-92. Epub 2009 Jan 27.
- Erratum in:
- Integr Cancer Ther. 2009 Jun;8(2):195.
Inhibitive effect of artemether on tumor growth and angiogenesis in the rat C6 orthotopic brain gliomas model.
Wu ZP, Gao CW, Wu YG, Zhu QS, Yan Chen, Xin Liu, Chuen Liu.
Cancer Institute, The 3rd Affiliated Hospital of Kunming Medical College, Yunnan University, Kunming 650091, China. [corrected]
explore the inhibitive effect of artemether on glioma growth and
angiogenesis in brain tumor bearing SD rat. MTT assay was used to
evaluate the inhibitory effect of artemether treatment on C6 glioma
cells. Forty SD rats which were subcutaneous planted with SD rat C6
glioma cell to establish SD rat orthotopic glioma model were divided
resourcefully into 5 groups. each group was 8 rats. Length-path (a mm)
and short-path (b mm) of tumor each rat was measured. Tumor volume was
calculated using the following formula: V (mm(3)) = a(2)bpi/6.
Microvessel density (MVD) in different therapy groups was significantly
lower than that in normal saline control group and brain glioma volume
in different therapy groups was significantly smaller than that in
normal saline control group. There were remarkably inhibitory effects
of artmeter on brain glioma growth and angiogenesis in SD rats and the
mechanism that artemether inhibited brain glioma growth might be
penetrating the blood-brain barrier and inhibiting angiogenesis.