- Dose Response. 2009 Mar 24;7(3):208-20.
The emerging low-dose therapy for advanced cancers.
Department of Radiation Oncology, Albany Medical Center, Albany, NY.
minute doses of drugs have been prescribed in biotherapies, homeopathy,
immunization and vaccinations for centuries. Now the use of low doses
of drugs is on the rise to combat serious diseases such as advanced
cancers around the world. This new therapeutic approach to address
solid tumors and other advanced diseases is a departure from the
conventional use of maximum dose protocol. A small dose of the
prescribed drug is frequently administered in a continuous fashion, at
regular intervals, either as a standard treatment or as a maintenance
therapy for a long time. However, this new treatment method lacks any
standard for drug quantization, dose fractionation, repetition
frequency and duration of a treatment course for an individual patient.
This paper reviews literature about metronomic therapy and discusses
hormesis: both phenomena occur in low dose ranges. Better mathematical
models, computer simulations, process optimization and clinical trials
are warranted to fully exploit the potential of low dose metronomic
therapy to cure chronic and complicated diseases. New protocols to
standardize metronomic dosimetry will answer the age old questions
related to hormesis and homeopathy. It appears that this new low-dose
metronomic therapy will have far reaching effects in curing chronic
diseases throughout the world.