J Support Oncol. 2009 Sep-Oct;7(5):158-67.
A 4-week home-based aerobic and resistance exercise program during radiation therapy: a pilot randomized clinical trial.
Mustian KM, Peppone L, Darling TV, Palesh O, Heckler CE, Morrow GR.
of Rochester School of Medicine and Dentistry, James P Wilmot Cancer
Center, Department of Radiation Oncology, Behavior Medicine Unit,
Rochester, NY 14642, USA.
radiation therapy, cancer patients may report cancer-related fatigue
(CRF), which impairs aerobic capacity, strength, muscle mass, and,
ultimately, quality of life (QOL). The purpose of this pilot clinical
trial was to examine the feasibility and initial efficacy of a
home-based aerobic and progressive resistance exercise intervention for
aerobic capacity, strength, muscle mass, CRF, and QOL. Daily steps
walked (DSW), daily minutes of resistance exercise (MRE), and number of
resistance exercise days (RED) were assessed to evaluate intervention
Breast and prostate cancer patients (n = 38) beginning
radiation therapy were randomized to undergo 4 weeks of exercise or no
exercise. Participants in the exercise group demonstrated good
adherence to the exercise intervention, with significantly more DSW,
MRE, and RED at post intervention and 3 month follow-up than controls.
Participants in the exercise intervention exhibited significantly
higher QOL and significantly lower CRF post intervention and at 3-month
follow-up than controls. Results of this pilot study provide positive
preliminary evidence that exercise during radiation may be beneficial
for cancer patients.