Cancer preventive effect of Morinda citrifolia (Noni).

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Ann N Y
Acad Sci.
2001 Dec;952:161-8.
preventive effect of Morinda citrifolia (Noni).

, Su
Department of Pathology, UIC College of
Medicine, Rockford, Illinois 61107, USA.

Morinda citrifolia (Noni) has been extensively
used in folk medicine by Polynesians for over 2,000 years. It has been
reported to have broad therapeutic effects, including anticancer
activity, in both clinical practice and laboratory animal models. The
mechanism for these effects remains unknown. The hypothesis that Morinda
citrifolia possesses a cancer preventive effect at the initiation stage
of carcinogenesis was studied. Our preliminary data indicated that 10%
Tahitian Noni Liquid Dietary Supplement or Tahitian Noni Juice (TNJ),
made from Morinda citrifolia fruit by Morinda Inc, in drinking water for
one week was able to prevent DMBA-DNA adduct formation. The levels of
DMBA-DNA adducts were reduced by 30% in the heart, 41% in the lung, 42%
in the liver, and 80% in the kidney of female SD rats. Even more
dramatic results were obtained in male C57 BL-6 mice: 10% TNJ was able
to reduce DMBA-DNA adduct formation by 60% in the heart, 50% in the
lung, 70% in the liver, and 90% in the kidney. In order to explore the
mechanism of this preventive effect, the antioxidant activity of TNJ was
examined in vitro by lipid hydroperoxide (LPO) and tetrazolium
nitroblue (TNB) assays. In the LPO assay, LPO oxidizes leucomethylene
blue to methylene blue in the presence of hemoglobin. The resultant blue
color was quantified at 660 nm spectrophotometrically. In the TNB
assay, superoxide anion radicals (SAR) reduce TNB into formazan blue
that was also measured by absorption at 602 nm. TNJ showed a
dose-dependent inhibition of both LPO and SAR in our system. The
antioxidant activity of TNJ was compared to the effects of vitamin C,
grape seed powder (GSP), and pycnogenol (PYC) at the daily dose per
serving level recommended by U.S.RDAs or manufacturers. The results
suggest that prevention of carcinogen-DNA adduct formation and the
antioxidant activity of TNJ may contribute to the cancer preventive
effect of Morinda citrifolia.