Drugs Exp Clin Res. 1998;24(5-6):281-5.
Morphometric and kinetic analysis of the growth of experimental sarcoma-45 in the presence of Ukrain.
Department of Pathology, Teaching Hospital #10, Kiev, Ukraine.
The effect of the antitumor agent Ukrain on the growth kinetics of the experimental tumor sarcoma-45 was studied by correlation analysis. Sarcoma-45 was implanted into 28 Wistar rats in the subcutaneous layer of a lateral site of the trunk. Fourteen animals received i.v. Ukrain every other day in a dose of 30 mg/kg (0.1 LD50). The other 14 rats served as controls. Macromorphometry of the tumor nodes of sarcoma-45 was carried out every day in both groups. Statistical analysis of morphometric data and plotting of histograms were performed. Regression equations were selected and their parameters determined. A mathematical model was assessed. The effectiveness of Ukrain treatment was analyzed using the equivalent exponent method. Ukrain was proved to be an effective antitumor agent on biological and mathematical models in accordance with standardized instructions for screening.